New Blood Test Could Predict Pregnancy Due Date And Premature Births
09 June, 2018, 22:09 | Author: Sherman Richardson
Specifically, the team targeted the RNA in the mother's blood.
"By measuring cell-free RNA in the circulation of the mother, we can observe changing patterns of gene activity that happen normally during pregnancy, and identify disruptions in the patterns that may signal to doctors that unhealthy circumstances like preterm labor and birth are likely to occur", Stevenson said.
There have been several studies on preterm births in the past, and the reasons for it. Previously, the best available tests for predicting premature birth worked only in high-risk women, such as those who had already given birth prematurely, and were correct only about 20 percent of the time. It was as accurate as the current method of ultrasound and more accurate than guesses based on woman's last menstrual period.
The leading cause of complications and neonatal death is preterm birth, which affects approximately 15 million births a year worldwide. Provisional data for 2017 from the National Center for Health Statistics show that the preterm birth rate in the USA has reached 9.93%, up from 9.86% in 2016, the third consecutive annual increase after steady declines over the previous seven years.
Quake's team found that, in women at increased risk of preterm delivery, the blood test predicted premature labor with 75 to 80 percent accuracy.
Preterm births occur in approximately 12 percent of all live births in the US - and it is the cause of about 70 percent of newborn deaths, according to the American College of Obstetrics and Gynecology. Ultrasound measurements and measures of fetal fibronectin (fFN) have similarly had low positive predictive value. "To date, no test on the market can reliably predict which pregnant moms will go on to preterm labor".
The gestational-age test was developed by studying a cohort of 31 women who gave blood weekly throughout their full-term pregnancies.
Ministers in Spain's female-dominated Cabinet take office
Spain's new Socialist government - featuring a groundbreaking female-dominated Cabinet - was sworn in by King Felipe VI Thursday. To maintain "stability", Sanchez has also promised to implement the 2018 budget crafted by the previous conservative government.
He added that the findings affirm the existence of a "transcriptomic clock of pregnancy" that could serve as a new way to assess the gestational age of a foetus. Further development and validation of an initial model resulted in the identification of a panel nine placenta-specific RNAs (CGA, CAPN6, CGB, ALPP, CSHL1, PLAC4, PSG7, PAPPA, and LGALS14) in maternal blood that could predict gestational age. "It tells us a lot about human development in normal pregnancy".
The same approach can also be used during the first trimester to estimate the due date with about 45 percent accuracy - a rate similar to ultrasound, a more expensive and invasive test.
When will a pregnant woman actually deliver her baby?
Though his daughter is now 16 and doing well, the preemie experience stuck with the dad, who hopes the tests could help understand and reduce preterm births.
The study to predict women's due dates included expectant mothers in Denmark who submitted a blood sample each week throughout their pregnancies.
Now, using powerful genetic techniques, Stanford scientists are closing in on that dream with a preliminary tool that requires only a pregnant woman's blood sample.
Durant is finishing the first year of his two-year, $51 million contract that includes an opt-out clause for the 2018-19 season. They could follow the blueprint the Houston Rockets used to compete against the Warriors in the Western Conference Finals.
Hansen about "the sacrifices and the cost-on Armstrong and on the nation-of one of the most risky missions in history". This trailer was first aired on ABC's Jimmy Kimmel Live tonight before it arrived online for all to see.
Gardner and Warren, both supporters of marijuana legalization by states, developed the bill in response to Sessions' action. The legislation would ensure states have the right to determine the best approach to marijuana within their borders.
Patrick High School in Elizabeth, where he played for one of the best high school coaches in the country - Kevin Boyle. Smith, the three-time National Basketball Association champ will meet with the Golden State Warriors this summer.
One of China's largest telecommunications companies is back on its feet today, thanks to a deal with the USA government. In addition, the company is agreeing to retain a team of special compliance coordinators selected by US regulators.
He added that eight Taliban attackers were killed and more than a dozen others were wounded during the gun battle. But Nicholson said his troops would not hesitate to respond if the Taliban broke the ceasefire.
The head of state, who travelled in an Ascot Landau, wore a sky blue coat and dress by Stuart Parvin, and a hat by Angela Kelly. The outing was also one of the first that Meghan Markle and Prince Harry had attended together since tying the knot in May.
Chrissy Teigen - who recently took part in an episode of Chase Sapphire's "Talking Travel" series - tweeted: "Anthony". "We'll miss him", Obama wrote on Twitter , accompanying the photo, taken by his White House photographer Pete Souza.
They offered "common-sense" recommendations for public companies to improve governance and relations with shareholders. A less compelling argument is that corporate EPS guidance more or less anchors analysts' EPS estimates.
IBF strips Golovkin of middleweight title
Golovkin's "unsanctioned fight" against Vanes Martirosyan on May 5 was cited as the main reason to strip him of the title. Promoter Lou DiBella and Derevyanchenko then tried to get the IBF to enforce a fight between Golovkin and Derevyanchenko.
This CO2 machine could transform the way we fight climate change
It's not just theory-Carbon Engineering's facility in British Columbia is already achieving both CO2 capture and fuel generation. Harvard researchers have found a cost-effective way to remove emitted carbon dioxide from the atmosphere, and turn it into fuel.
Verizon names former Ericsson chief as new CEO
John Stratton , Verizon's president of global operations, was expected to succeed current Lowell McAdam, according to analysts. He also led the acquisitions of major media, fiber and telematics assets, including AOL Inc., Yahoo!
Rafael Nadal reaches record 11th French Open final
He'll now face Thiem who's arguably been the best player besides Rafael Nadal in the clay court season. The Argentinian had forced six break points during the first set but each time Nadal fended them off.
At least 18 killed and dozens wounded in Baghdad blasts
The council ditched the leadership of the election commission and made a decision to annul votes from Iraqis out of the country. Those include a manual recount of at least 5 per cent of ballots and annulling all votes from overseas and displaced voters.
How to get help for someone who might be suicidal
You can learn more about its services here, including its guide on what to do if you see suicidal language on social media . The other two are Alzheimer's disease and drug overdose, in part because of the spike in opioid deaths, said Dr.